Can Any of These NFL Week 5 Underdogs Pull Off a Shocker?
Cats as Dogs? Giants Turned Davids?

Giants are Aptly Named as Week 5’s Biggest Underdogs
And just like that, the Chicago). How else will you be a 12-point underdog, the biggest of Week 5, against a team that just got blown out by 28 points? It’s not looking great for Brian Daboll’s embattled team against Miami. But they’re not the only big NFL Week 5 underdogs. ing the Giants are a pair of cat-themed squads.
Can Jaguars Ambush Bills Again?
- Opponent: Buffalo Bills (Neutral territory)
- Point Spread: Jacksonville Jaguars +6 (-115)
- Moneyline: +205
The Jaguars’ Josh Allen is unlikely to have as impactful of a game as he did the last time these teams met (2021). He had eight tackles and forced two turnovers from the Bills’ Josh Allen as Jacksonville held Buffalo to six points to complete the upset at +625 or wider.
That was the Bills’ worst game. NFL game odds this week.
Jacksonville may have more of a home-turf advantage here as the team is already in acclimated to London. But we have a tough time picking a questionable offense, especially against Buffalo’s top-ranked rush. And Buffalo now has an improved running game outside of Allen. The Bills might just exact revenge here.
Pick: Buffalo Bills -250
Panthers are Prey Against the Lions
- Opponent: Detroit Lions
- Point Spread: Carolina Panthers +10 (-110)
- Moneyline: +385
We mentioned the Giants and Bears as the worst NFL injuries list in just his third week. And when he’s healthy, he can’t do much thanks to a subpar offense around him.
The Panthers are now rumored to be in the market for a top receiver. That will barely change its fortunes. Young is still not protected well enough even against a mediocre rush from the Lions. Even with an extra 10 points, it’s tough to trust this team as NFL Week 5 underdogs.
Detroit is scoring 26.5 points a game against Carolina’s 16.8. The Lions’ prolific rushing attack will also wear out Carolina’s defense. The Lions maul the Panthers in this catfight.
Pick: Detroit Lions -10 (-110)
Giants’ Odds Keep Getting Bigger Against Dolphins
- Opponent: Miami Dolphins
- Point Spread: New York Giants +12 (-110)
- Moneyline: +490
Friends don’t let friends bet on the New York Giants even at +12 or 5-1 on the moneyline. But we’ll play a bit of devil’s advocate here. Can the Giants shock the world as the biggest NFL Week 5 underdogs? It’s not impossible. But the Dolphins will have to “help” them.
For one, Miami’s defense stinks. Vic Fangio has not worked his magic on this team yet. Miami is allowing opposing quarterbacks a 104.9 er rating, which is higher than only four other defenses. And while the team is generating enough pressure (25.8%), the team’s secondary is giving up plenty of yardage.
So, maybe the Giants can get its lifeless offense going. But maybe not. The New England, another terrible offense, to just 17 points. The Giants are scoring the fewest points (11.5) and second-fewest yards (252). The defense is the only one that has yet to force a turnover. It’s why the G-Men are the only 0-4 team ATS. Bet Miami or just .
Pick: Dolphins -12 (-110)
For Point Spreads Sports Magazine.
Can’t get enough? Here’s more!
- Eagles vs Rams Odds: So Far, So Good for Unbeaten Philadelphia
- Chiefs vs Vikings Preview: Are The Chiefs Overrated Heading Into Week 5?
- Bengals vs Cardinals Preview: Cincinnati Offense Struggling
- Jets vs Broncos Odds Preview: Two Bad Teams But a Good Total?
- NFL Lines Week 5: Finding Value on Totals This Week