Southern California vs Colorado Expert Picks: Reality Check Awaits Coach Prime?
Betting Public Backing USC as Line Grows From 17.5 to 21.5

Unbeaten no more, it’s back to the drawing board for the Arizona State.
After opening as 17.5-point favorites, the Trojans are now -21.5 (-110) and -1200 to win outright. Meanwhile, Colorado is +21.5 (-110) on the spread and +750 on the moneyline. The projected total is 73.5 (-110 Over, -110 Under).
Do the Trojans have what it takes to cover? Or are the Buffaloes poised to bounce back? Read on as we break down the Southern California vs Colorado odds in our game preview.
Trojans vs Buffaloes Betting Trends
The USC Trojans are 2-2 against the spread this season and 2-4 over their last six games. The total has gone Over in 11 of their last 12 games. Meanwhile, the Colorado Buffaloes are just 4-12 ATS over their last 16 games. In 11 of their last 15 contests, the total has gone Over. That’s important to when assessing the Southern California vs Colorado odds.
Pump the Brakes on Colorado
The Colorado Buffaloes finally met their match last week, losing 42-6 to No. 10 Oregon. With that, the Buffaloes’ (3-1, 2-2 ATS) undefeated start ended. So, too, did their stay in the AP Top 25 NCAAF rankings. And their buzz as a darkhorse national championship contender? Yes, that came to a halt as well.
The Buffaloes, who had taken the college football world by storm under new head coach Deion Sanders, reminded everyone just how far they still have to go to become a legitimate contender. In many ways, it was a necessary reality check for a program coming off a 1-11 last season.
Shedeur Sanders — the son of the former Hall of Fame cornerback — has been instrumental in Colorado’s stirring start, with 11 touchdown es compared to only one interception. But his college football championship odds dropped. The Buffaloes entered Saturday with +11000 odds to win it all. Those odds are now +25000.
Oregon exposed many of Colorado’s flaws, outgaining the Buffaloes 522-199 while sacking Sanders seven times. So, while the Buffaloes — who were projected for just 3.5 wins — are on pace to crush expectations, it’s still best to temper some of the enthusiasm around the program.
Keep in mind, the Buffaloes are still without arguably their biggest playmaker in Travis Hunter. The two-way star suffered a lacerated liver due to a late hit in a 43-35 double overtime win over Colorado State on Sept. 16.
As Goes Williams, So Go the Trojans
The USC Trojans have been as good as d through four weeks. The No. 8 Trojans are averaging an FBS-best 55 points per game and rank third in yards (569.2/game). They’re 4-0 but just 2-2 ATS.
The key to their success, of course, is no secret. It starts — and ends — with 2024 NFL Draft.
Unsurprisingly, oddsmakers remain bullish on USC. The Trojans — who were projected for 10.0 wins — remain a +230 favorite to win the Pac 12 and are +1400 to win it all. Those are the sixth-best odds on the board, trailing two-time defending national champion Ohio State.
The Trojans will have plenty of opportunities to improve their resume down the stretch, with four of their last eight games against ranked opponents. And that doesn’t include this week’s clash against the Buffaloes, who dropped from No. 19 in the AP poll to outside the Top 25.
For Point Spreads Sports Magazine.
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